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 Previous Article

Eukaryotic Cell, December 2008, p. 2179-2183, Vol. 7, No. 12
1535-9778/08/$08.00+0     doi:10.1128/EC.00262-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Insight into the Role of HOG Pathway Components Ssk2p, Pbs2p, and Hog1p in the Opportunistic Yeast Candida lusitaniae{triangledown} ,{dagger}

Stéphanie Boisnard, Gwenaël Ruprich-Robert, Martine Florent, Bruno Da Silva, Florence Chapeland-Leclerc, and Nicolas Papon*

Programme Chimiorésistance des Levures Pathogènes, EA209 Eucaryotes Pathogènes: Transports Membranaires et Chimiorésistance, UFR des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, 75006 Paris, France

Received 4 August 2008/ Accepted 15 October 2008

In the present study, we have investigated the role of SSK2, PBS2, and HOG1, encoding modules of the high-osmolarity-glycerol mitogen-activated protein kinase pathway in Candida lusitaniae. Functional analysis of mutants indicated that Ssk2p, Pbs2p, and Hog1p are involved in osmotolerance, drug sensitivity, and heavy metal tolerance but not in oxidant stress adaptation.

* Corresponding author. Mailing address: Programme Chimiorésistance des Levures Pathogènes, EA209 Eucaryotes Pathogènes: Transports Membranaires et Chimiorésistance, UFR des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, 4 avenue de l'Observatoire, 75006 Paris, France. Phone: (33) 1 53 73 96 42. Fax: (33) 1 53 73 96 40. E-mail: nicolas.papon{at}univ-paris5.fr

{triangledown} Published ahead of print on 24 October 2008.

{dagger} Supplemental material for this article may be found at http://ec.asm.org/.

Eukaryotic Cell, December 2008, p. 2179-2183, Vol. 7, No. 12
1535-9778/08/$08.00+0     doi:10.1128/EC.00262-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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