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Eukaryotic Cell, November 2008, p. 2008-2011, Vol. 7, No. 11
1535-9778/08/$08.00+0     doi:10.1128/EC.00105-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Hydrogen Peroxide Induces Hyphal Differentiation in Candida albicans{triangledown}

Olviyani Nasution,1 Kavitha Srinivasa,1 Minsun Kim,1 Yeo-Jung Kim,1 Wankee Kim,3 Woojin Jeong,1 and Wonja Choi1,2*

Division of Life and Pharmaceutical Sciences,1 Microbial Resources Research Center, Ewha Womans University, Seoul 120-750, South Korea,2 Institute for Medical Sciences, School of Medicine, Ajou University, Suwon 442-749, South Korea3

Received 24 March 2008/ Accepted 3 September 2008

In this study, we demonstrate that hyphal differentiation is induced by the subtoxic concentration of exogenous H2O2 in Candida albicans. This finding is confirmed by the changing intracellular concentration of H2O2. In order to induce the same level of differentiation, low concentrations of exogenous H2O2 are required for the null mutants of the thiol-specific antioxidant and catalase, while higher concentrations are needed for cells treated with ascorbic acid, an antioxidant chemical.

* Corresponding author. Mailing address: Science Building A, Room 211, Ewha Womans University, Seoul 120-750, South Korea. Phone: 82-2-3277-2892. Fax: 82-2-3277-2385. E-mail: wjchoi{at}ewha.ac.kr

{triangledown} Published ahead of print on 12 September 2008.

Eukaryotic Cell, November 2008, p. 2008-2011, Vol. 7, No. 11
1535-9778/08/$08.00+0     doi:10.1128/EC.00105-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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