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Eukaryotic Cell, April 2007, p. 609-615, Vol. 6, No. 4
1535-9778/07/$08.00+0     doi:10.1128/EC.00010-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Expression and Interstrain Variability of the YPS3 Gene of Histoplasma capsulatum{triangledown}

Megan L. Bohse and Jon P. Woods*

Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison, Wisconsin 53706

Received 8 January 2007/ Accepted 20 February 2007

The YPS3 locus of the dimorphic fungus Histoplasma capsulatum encodes a secreted and surface-localized protein specific to the pathogenic yeast phase. In this study we examined this locus in 32 H. capsulatum strains and variants. Although protein production is limited to a select group of strains, the North American restriction fragment length polymorphism class 2/NAm 2 isolates, the locus was present in all the strains we examined. The YPS3 gene is well conserved in its 5' and 3' regions but displays an intragenic hypervariable region of tandem repeats that fluctuates in size between strains. This feature is similar to that seen with genes encoding several cell surface proteins in other fungi.

* Corresponding author. Mailing address: Department of Medical Microbiology and Immunology, 420 SMI, University of Wisconsin Medical School, 1300 University Avenue, Madison, WI 53706. Phone: (608) 265-6292. Fax: (608) 265-6132. E-mail: jpwoods{at}wisc.edu

{triangledown} Published ahead of print on 2 March 2007.

Eukaryotic Cell, April 2007, p. 609-615, Vol. 6, No. 4
1535-9778/07/$08.00+0     doi:10.1128/EC.00010-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Cooper, K. G., Woods, J. P. (2009). Secreted Dipeptidyl Peptidase IV Activity in the Dimorphic Fungal Pathogen Histoplasma capsulatum. Infect. Immun. 77: 2447-2454 [Abstract] [Full Text]  
  • Gutierrez, M. E., Canton, A., Connolly, P., Zarnowski, R., Wheat, L. J. (2008). Detection of Histoplasma capsulatum Antigen in Panamanian Patients with Disseminated Histoplasmosis and AIDS. CVI 15: 681-683 [Abstract] [Full Text]  
  • Bohse, M. L., Woods, J. P. (2007). RNA Interference-Mediated Silencing of the YPS3 Gene of Histoplasma capsulatum Reveals Virulence Defects. Infect. Immun. 75: 2811-2817 [Abstract] [Full Text]  


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