Eukaryotic Cell, February 2007, p. 346-350, Vol. 6, No. 2
1535-9778/07/$08.00+0 doi:10.1128/EC.00336-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine,1 Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan2
Received 19 October 2006/ Accepted 28 November 2006
Many single-celled eukaryotes produce prostaglandin-like molecules, but these have not been absolutely verified by mass spectrometry. We have isolated, and identified by liquid chromatography-tandem mass spectrometry, authentic prostaglandin E2 from Cryptococcus neoformans. Cyclooxygenase inhibitors did not inhibit prostaglandin synthesis, and the cryptococcal genome lacks a cyclooxygenase homolog. Thus, novel enzymes must exist.
Published ahead of print on 8 December 2006.
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