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 Previous Article

Eukaryotic Cell, February 2007, p. 346-350, Vol. 6, No. 2
1535-9778/07/$08.00+0     doi:10.1128/EC.00336-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Cryptococcus neoformans Produces Authentic Prostaglandin E2 without a Cyclooxygenase{triangledown}

John R. Erb-Downward and Gary B. Huffnagle*

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine,1 Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan2

Received 19 October 2006/ Accepted 28 November 2006

Many single-celled eukaryotes produce prostaglandin-like molecules, but these have not been absolutely verified by mass spectrometry. We have isolated, and identified by liquid chromatography-tandem mass spectrometry, authentic prostaglandin E2 from Cryptococcus neoformans. Cyclooxygenase inhibitors did not inhibit prostaglandin synthesis, and the cryptococcal genome lacks a cyclooxygenase homolog. Thus, novel enzymes must exist.

* Corresponding author. Mailing address: Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0642. Phone: (734) 936-9368. Fax: (734) 764-4556. E-mail: ghuff{at}umich.edu.

{triangledown} Published ahead of print on 8 December 2006.

Eukaryotic Cell, February 2007, p. 346-350, Vol. 6, No. 2
1535-9778/07/$08.00+0     doi:10.1128/EC.00336-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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