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 Previous Article

Eukaryotic Cell, December 2007, p. 2448-2452, Vol. 6, No. 12
1535-9778/07/$08.00+0     doi:10.1128/EC.00321-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Functional Characterization of Pneumocystis carinii brl1 by Transspecies Complementation Analysis{triangledown} ,{dagger}

Libera Lo Presti,1,{ddagger} Moira Cockell,1,{ddagger} Lorenzo Cerutti,2,§ Viesturs Simanis,3 and Philippe M. Hauser1*

Institute of Microbiology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland,1 Swiss Institute of Bioinformatics, Lausanne, Switzerland,2 Cell Cycle Control Laboratory, Swiss Institute for Experimental Cancer Research (ISREC), and School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Epalinges, Switzerland3

Received 28 August 2007/ Accepted 19 October 2007

Pneumocystis jirovecii is a fungus which causes severe opportunistic infections in immunocompromised humans. The brl1 gene of P. carinii infecting rats was identified and characterized by using bioinformatics in conjunction with functional complementation in Saccharomyces cerevisiae and Schizosaccharomyces pombe. The ectopic expression of this gene rescues null alleles of essential nuclear membrane proteins of the Brr6/Brl1 family in both yeasts.

* Corresponding author. Mailing address: Institute of Microbiology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, 1011 Lausanne, Switzerland. Phone: 41 021 3144084. Fax: 41 021 3144060. E-mail: philippe.hauser{at}chuv.ch

{triangledown} Published ahead of print on 9 November 2007.

{dagger} Supplemental material for this article may be found at http://ec.asm.org/.

{ddagger} These authors contributed approximately equally to this work.

§ Present address: Ludwig Institute for Cancer Research, Lausanne, Switzerland.

Eukaryotic Cell, December 2007, p. 2448-2452, Vol. 6, No. 12
1535-9778/07/$08.00+0     doi:10.1128/EC.00321-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Beck, J. M., Cushion, M. T. (2009). Pneumocystis Workshop: 10th Anniversary Summary. Eukaryot Cell 8: 446-460 [Full Text]  
  • Cockell, M. M., Lo Presti, L., Cerutti, L., Cano Del Rosario, E., Hauser, P. M., Simanis, V. (2009). Functional Differentiation of tbf1 Orthologues in Fission and Budding Yeasts. Eukaryot Cell 8: 207-216 [Abstract] [Full Text]  


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