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 Previous Article

Eukaryotic Cell, August 2006, p. 1441-1445, Vol. 5, No. 8
1535-9778/06/$08.00+0     doi:10.1128/EC.00160-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Fungal Metabolic Model for Tyrosinemia Type 3: Molecular Characterization of a Gene Encoding a 4-Hydroxy-Phenyl Pyruvate Dioxygenase from Aspergillus nidulans

Márcia Eliana da Silva Ferreira,1 Marcela Savoldi,1 Pierina Sueli Bonato,1 Maria Helena S. Goldman,2 and Gustavo H. Goldman1*

Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil,1 Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil2

Received 12 April 2006/ Accepted 6 June 2006

Mutations in the human HPD gene (encoding 4-hydroxyphenylpyruvic acid dioxygenase) cause hereditary tyrosinemia type 3 (HT3). We deleted the Aspergillus nidulans homologue (hpdA). We showed that the mutant strain is not able to grow in the presence of phenylalanine and that it accumulates increased concentrations of tyrosine and 4-hydroxyphenylpyruvic acid, mimicking the human HT3 phenotype.

* Corresponding author. Mailing address: Departamento de Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Av. do Café S/N, CEP 14040-903, Ribeirão Preto, São Paulo, Brazil. Phone: 55-16-6024280. Fax: 55-16-6331092. E-mail: ggoldman{at}usp.br.

Eukaryotic Cell, August 2006, p. 1441-1445, Vol. 5, No. 8
1535-9778/06/$08.00+0     doi:10.1128/EC.00160-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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