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 Previous Article

Eukaryotic Cell, July 2006, p. 1169-1173, Vol. 5, No. 7
1535-9778/06/$08.00+0     doi:10.1128/EC.00040-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Plasmodium falciparum AMA1 Binds a Rhoptry Neck Protein Homologous to TgRON4, a Component of the Moving Junction in Toxoplasma gondii

David L. Alexander,1 Shirin Arastu-Kapur,1,2 Jean-Francois Dubremetz,3 and John C. Boothroyd1*

Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305-5124,1 Department of Pathology, Stanford University School of Medicine, Stanford, California 94305-5324,2 UMR 5539 CNRS, Université de Montpellier 2, CP 107, Place Eugène Bataillon, 34090 Montpellier, France3

Received 8 February 2006/ Accepted 1 May 2006

Plasmodium falciparum apical membrane antigen 1 (PfAMA1) coimmunoprecipitates with the Plasmodium homologue of TgRON4, a secreted rhoptry neck protein of Toxoplasma gondii that migrates at the moving junction in association with TgAMA1 during invasion. PfRON4 also originates in the rhoptry necks, suggesting that this unusual collaboration of micronemes and rhoptries is a conserved feature of Apicomplexa.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305-5124. Phone: (650) 723-7984. Fax: (650) 723-6853. E-mail: john.boothroyd{at}stanford.edu.

Eukaryotic Cell, July 2006, p. 1169-1173, Vol. 5, No. 7
1535-9778/06/$08.00+0     doi:10.1128/EC.00040-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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