Previous Article | Next Article 
Eukaryotic Cell, May 2006, p. 871-875, Vol. 5, No. 5
1535-9778/06/$08.00+0 doi:10.1128/EC.5.5.871-875.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.
Stress by Heat Shock Induces Massive Down Regulation of Genes and Allows Differential Allelic Expression of the Gal/GalNAc Lectin in Entamoeba histolytica
Christian Weber,1
Ghislaine Guigon,2
Christiane Bouchier,2
Lionel Frangeul,2
Sandrine Moreira,2
Odile Sismeiro,2
Catherine Gouyette,2
David Mirelman,3
Jean Yves Coppee,2 and
Nancy Guillén1*
Unité Biologie Cellulaire du Parasitisme, INSERM 786, Institut Pasteur, 28 rue du Dr. Roux, 75724 Paris Cedex 15, France,1
Pasteur Genopole Île-de-France, Institut Pasteur, 28 rue du Dr. Roux, 75724 Paris Cedex 15, France,2
Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, Israel3
Received 8 December 2005/
Accepted 21 February 2006
Gene expression analysis by microarray assay revealed that when exposed to stress, Entamoeba histolytica exhibits a specific heat shock response, together with a dramatic overall reduction in gene transcription as well as differential allelic expression of key genes participating in virulence, such as the galactose/N-acetylgalactosamine (Gal/GalNAc) lectin.
* Corresponding author. Mailing address: Unité Biologie Cellulaire du Parasitisme, INSERM 786, Institut Pasteur, 28 rue du Dr. Roux, 75724 Paris Cedex 15, France. Phone: 331-45688675. Fax: 331-45688674. E-mail:
nguillen{at}pasteur.fr.
Supplemental material for this article may be found at http://ec.asm.org/.
Eukaryotic Cell, May 2006, p. 871-875, Vol. 5, No. 5
1535-9778/06/$08.00+0 doi:10.1128/EC.5.5.871-875.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.
This article has been cited by other articles:
-
Clement-Ziza, M., Malabat, C., Weber, C., Moszer, I., Aittokallio, T., Letondal, C., Rousseau, S.
(2009). Genoscape: a Cytoscape plug-in to automate the retrieval and integration of gene expression data and molecular networks. Bioinformatics
25: 2617-2618
[Abstract]
[Full Text]
-
Abhyankar, M. M., Hochreiter, A. E., Hershey, J., Evans, C., Zhang, Y., Crasta, O., Sobral, B. W. S., Mann, B. J., Petri, W. A. Jr., Gilchrist, C. A.
(2008). Characterization of an Entamoeba histolytica High-Mobility-Group Box Protein Induced during Intestinal Infection. Eukaryot Cell
7: 1565-1572
[Abstract]
[Full Text]
-
Hackney, J. A., Ehrenkaufer, G. M., Singh, U.
(2007). Identification of putative transcriptional regulatory networks in Entamoeba histolytica using Bayesian inference. Nucleic Acids Res
35: 2141-2152
[Abstract]
[Full Text]