Eukaryotic Cell
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Eukaryotic Cell, December 2006, p. 2184-2188, Vol. 5, No. 12
1535-9778/06/$08.00+0     doi:10.1128/EC.00274-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Genetic Architecture of Hsp90-Dependent Drug Resistance{triangledown}

Leah E. Cowen,1 Anne E. Carpenter,1 Oranart Matangkasombut,2 Gerald R. Fink,1 and Susan Lindquist1*

Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142,1 Department of Microbiology, School of Dentistry, Chulalongkorn University, Bangkok 10330, Thailand2

Received 28 August 2006/ Accepted 11 October 2006

Hsp90 potentiates the evolution of azole resistance in the model yeast Saccharomyces cerevisiae and the opportunistic pathogen Candida albicans via calcineurin. Here, we explored effectors downstream of calcineurin regulating this Hsp90-dependent trait. Using S. cerevisiae erg3 mutants as a model, we determined that both Crz1 and Hph1 modulate azole resistance.

* Corresponding author. Mailing address: Whitehead Institute, Nine Cambridge Center, Cambridge, MA 02142. Phone: (617) 258-5184. Fax: (617) 258-5737. E-mail: Lindquist_admin{at}wi.mit.edu.

{triangledown} Published ahead of print on 20 October 2006.

Eukaryotic Cell, December 2006, p. 2184-2188, Vol. 5, No. 12
1535-9778/06/$08.00+0     doi:10.1128/EC.00274-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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