Eukaryotic Cell
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Eukaryotic Cell, November 2006, p. 1894-1905, Vol. 5, No. 11
1535-9778/06/$08.00+0     doi:10.1128/EC.00151-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Tcc1p, a Novel Protein Containing the Tetratricopeptide Repeat Motif, Interacts with Tup1p To Regulate Morphological Transition and Virulence in Candida albicans{triangledown} ,{dagger}

Aki Kaneko, Takashi Umeyama, Yuki Utena-Abe, Satoshi Yamagoe, Masakazu Niimi, and Yoshimasa Uehara*

Department of Bioactive Molecules, National Institute of Infectious Diseases, Tokyo 162-8640, Japan

Received 25 May 2006/ Accepted 28 August 2006

The transcriptional factor CaTup1p represses many genes involved in intracellular processes, including the yeast-hypha transition, in the human fungal pathogen Candida albicans. Using tandem affinity purification technology, we identified a novel protein that interacts with CaTup1p, named Tcc1p (Tup1p complex component). Tcc1p is a C. albicans-specific protein with a 736-amino-acid polypeptide with four tetratricopeptide repeat (TPR) motifs in the N-terminal portion. Tcc1p formed a protein complex with CaTup1p via the TPR domain of Tcc1p, independently of CaSsn6p-CaTup1p The tcc1{Delta} disruptant showed filamentous growth under conditions inducing the yeast form, as is true of the Catup1{Delta} mutant. Consistent with this result, the common set of hypha-specific genes was negatively regulated by both TCC1 and CaTUP1. These observations will provide new insights into CaTup1p-dependent transcriptional gene regulation in C. albicans.

* Corresponding author. Mailing address: Department of Bioactive Molecules, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan. Phone: 81 3 5285-1111. Fax: 81 3 5285-1175. E-mail: yuehara{at}nih.go.jp.

{triangledown} Published ahead of print on 22 September 2006.

{dagger} Supplemental material for this article may be found at http://ec.asm.org/.

Eukaryotic Cell, November 2006, p. 1894-1905, Vol. 5, No. 11
1535-9778/06/$08.00+0     doi:10.1128/EC.00151-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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