Eukaryotic Cell
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Eukaryotic Cell, October 2006, p. 1826-1830, Vol. 5, No. 10
1535-9778/06/$08.00+0     doi:10.1128/EC.00225-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Mitogen-Activated Protein Kinase Hog1 Is Essential for the Response to Arsenite in Saccharomyces cerevisiae{triangledown}

Jael Sotelo and Miguel A. Rodríguez-Gabriel*

Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain

Received 13 July 2006/ Accepted 11 August 2006

Here we describe, for the first time, that budding yeast mitogen-activated protein kinase Hog1 and its upstream activators Pbs2 and Ssk1 are essential for the response to arsenite. Hog1 is rapidly phosphorylated in response to arsenite and triggers a transcriptional response that involves the upregulation of genes essential for arsenite detoxification.

* Corresponding author. Mailing address: Departamento de Microbiología II. Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain. Phone: 34-91-3941755. Fax: 34-91-3941745. E-mail: miguelr{at}farm.ucm.es.

{triangledown} Published ahead of print on 18 August 2006.

Eukaryotic Cell, October 2006, p. 1826-1830, Vol. 5, No. 10
1535-9778/06/$08.00+0     doi:10.1128/EC.00225-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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