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Eukaryotic Cell, October 2006, p. 1826-1830, Vol. 5, No. 10
1535-9778/06/$08.00+0 doi:10.1128/EC.00225-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.
Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain
Received 13 July 2006/ Accepted 11 August 2006
Here we describe, for the first time, that budding yeast mitogen-activated protein kinase Hog1 and its upstream activators Pbs2 and Ssk1 are essential for the response to arsenite. Hog1 is rapidly phosphorylated in response to arsenite and triggers a transcriptional response that involves the upregulation of genes essential for arsenite detoxification.
Published ahead of print on 18 August 2006.
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