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Eukaryotic Cell, April 2005, p. 832-835, Vol. 4, No. 4
1535-9778/05/$08.00+0     doi:10.1128/EC.4.4.832-835.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

The Highly Conserved tRNAHis Guanylyltransferase Thg1p Interacts with the Origin Recognition Complex and Is Required for the G2/M Phase Transition in the Yeast Saccharomyces cerevisiae

Terri S. Rice,1 Min Ding,2 David S. Pederson,2 and Nicholas H. Heintz1*

Departments of Pathology,1 Microbiology and Molecular Genetics, Vermont Cancer Center, University of Vermont College of Medicine, Burlington, Vermont 054052

Received 28 September 2004/ Accepted 21 January 2005

Here we show that the Saccharomyces cerevisiae tRNAHis guanylyltransferase Thg1p interacts with the origin recognition complex in vivo and in vitro and that overexpression of hemagglutinin-Thg1p selectively impedes growth of orc2-1(Ts) cells at the permissive temperature. Studies with conditional mutants indicate that Thg1p couples nuclear division and migration to cell budding and cytokinesis in yeast.

* Corresponding author. Mailing address: Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405. Phone: (802) 656-0372. Fax: (802) 656-8892. E-mail: Nicholas.Heintz{at}uvm.edu.

Eukaryotic Cell, April 2005, p. 832-835, Vol. 4, No. 4
1535-9778/05/$08.00+0     doi:10.1128/EC.4.4.832-835.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Abad, M. G., Rao, B. S., Jackman, J. E. (2010). Template-dependent 3'-5' nucleotide addition is a shared feature of tRNAHis guanylyltransferase enzymes from multiple domains of life. Proc. Natl. Acad. Sci. USA 107: 674-679 [Abstract] [Full Text]  
  • Jackman, J. E., Phizicky, E. M. (2006). tRNAHis guanylyltransferase catalyzes a 3'-5' polymerization reaction that is distinct from G-1 addition. Proc. Natl. Acad. Sci. USA 103: 8640-8645 [Abstract] [Full Text]  
  • Gu, W., Hurto, R. L., Hopper, A. K., Grayhack, E. J., Phizicky, E. M. (2005). Depletion of Saccharomyces cerevisiae tRNAHis Guanylyltransferase Thg1p Leads to Uncharged tRNAHis with Additional m5C. Mol. Cell. Biol. 25: 8191-8201 [Abstract] [Full Text]  


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