Eukaryotic Cell
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Eukaryotic Cell, April 2005, p. 832-835, Vol. 4, No. 4
1535-9778/05/$08.00+0     doi:10.1128/EC.4.4.832-835.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

The Highly Conserved tRNAHis Guanylyltransferase Thg1p Interacts with the Origin Recognition Complex and Is Required for the G2/M Phase Transition in the Yeast Saccharomyces cerevisiae

Terri S. Rice,1 Min Ding,2 David S. Pederson,2 and Nicholas H. Heintz1*

Departments of Pathology,1 Microbiology and Molecular Genetics, Vermont Cancer Center, University of Vermont College of Medicine, Burlington, Vermont 054052

Received 28 September 2004/ Accepted 21 January 2005

Here we show that the Saccharomyces cerevisiae tRNAHis guanylyltransferase Thg1p interacts with the origin recognition complex in vivo and in vitro and that overexpression of hemagglutinin-Thg1p selectively impedes growth of orc2-1(Ts) cells at the permissive temperature. Studies with conditional mutants indicate that Thg1p couples nuclear division and migration to cell budding and cytokinesis in yeast.

* Corresponding author. Mailing address: Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405. Phone: (802) 656-0372. Fax: (802) 656-8892. E-mail: Nicholas.Heintz{at}uvm.edu.

Eukaryotic Cell, April 2005, p. 832-835, Vol. 4, No. 4
1535-9778/05/$08.00+0     doi:10.1128/EC.4.4.832-835.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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