Eukaryotic Cell
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Eukaryotic Cell, August 2004, p. 1062-1065, Vol. 3, No. 4
1535-9778/04/$08.00+0     DOI: 10.1128/EC.3.4.1062-1065.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

The Two-Component Signal Transduction Protein Chk1p Regulates Quorum Sensing in Candida albicans

Michael Kruppa,{dagger} Bastiaan P. Krom,{dagger} Neeraj Chauhan, Adrienne V. Bambach, Ronald L. Cihlar, and Richard A. Calderone*

Department of Microbiology & Immunology, Georgetown University Medical Center, Washington, D.C. 20057

Received 15 April 2004/ Accepted 27 April 2004

Regulation of hyphal morphogenesis in Candida albicans can occur through quorum sensing (QS). A QS signal, farnesol, is produced during high-density growth and inhibits morphogenesis. However, the signal transduction pathway that regulates QS is unknown. Here, we show that a C. albicans mutant lacking Chk1p but not either the Sln1p or the Nik1p histidine kinase is refractory to the inhibitory effect of farnesol both in cell suspension and during the formation of a biofilm. This study is the first to demonstrate a role for a two-component signal transduction protein in QS by a eukaryotic organism.

* Corresponding author. Mailing address: Department of Microbiology & Immunology, Georgetown University Medical Center, Washington, DC 20057. Phone: (202) 687-1137. Fax: (202) 687-1800. E-mail: calderor{at}georgetown.edu.

{dagger} M.K. and B.P.K. contributed equally to this work.

Eukaryotic Cell, August 2004, p. 1062-1065, Vol. 3, No. 4
1535-9778/04/$08.00+0     DOI: 10.1128/EC.3.4.1062-1065.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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Appl. Environ. Microbiol. Infect. Immun. J. Bacteriol.
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Copyright © 2004 by the American Society for Microbiology.