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Biosynthesis and Uptake of Siderophores Is Controlled by the PacC-Mediated Ambient-pH Regulatory System in Aspergillus nidulans

Martin Eisendle,^1, Harald Oberegger,^1,, Rudolf Buttinger,² Paul Illmer,² and Hubertus Haas^1*

Department of Molecular Biology, Medical University of Innsbruck,¹ Department of Microbiology, University of Innsbruck, A-6020 Innsbruck, Austria²

Received 20 November 2003/ Accepted 25 January 2004

Biosynthesis and uptake of siderophores in Aspergillus nidulans are regulated not only by iron availability but also by ambient pH: expression of this high-affinity iron uptake system is elevated by an increase in the ambient pH. Mediation of this regulation by the transcriptional regulator PacC has been confirmed via acidity- and alkalinity-mimicking mutants.

M.E. and H.O. contributed equally to this work.

Present address: Sandoz GmbH, A-6250 Kundl, Austria.

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