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Eukaryotic Cell, April 2004, p. 561-563, Vol. 3, No. 2
1535-9778/04/$08.00+0     DOI: 10.1128/EC.3.2.561-563.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Biosynthesis and Uptake of Siderophores Is Controlled by the PacC-Mediated Ambient-pH Regulatory System in Aspergillus nidulans

Martin Eisendle,1,{dagger} Harald Oberegger,1,{dagger},{ddagger} Rudolf Buttinger,2 Paul Illmer,2 and Hubertus Haas1*

Department of Molecular Biology, Medical University of Innsbruck,1 Department of Microbiology, University of Innsbruck, A-6020 Innsbruck, Austria2

Received 20 November 2003/ Accepted 25 January 2004

Biosynthesis and uptake of siderophores in Aspergillus nidulans are regulated not only by iron availability but also by ambient pH: expression of this high-affinity iron uptake system is elevated by an increase in the ambient pH. Mediation of this regulation by the transcriptional regulator PacC has been confirmed via acidity- and alkalinity-mimicking mutants.

* Corresponding author. Mailing address: Department of Molecular Biology, Medical University of Innsbruck, Peter-Mayr-Str. 4b/III, A-6020 Innsbruck, Austria. Phone: 43 512 507 3605. Fax: 43 512 507 2866. E-mail: hubertus.haas{at}uibk.ac.at.

{dagger} M.E. and H.O. contributed equally to this work.

{ddagger} Present address: Sandoz GmbH, A-6250 Kundl, Austria.

Eukaryotic Cell, April 2004, p. 561-563, Vol. 3, No. 2
1535-9778/04/$08.00+0     DOI: 10.1128/EC.3.2.561-563.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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