Eukaryotic Cell
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Eukaryotic Cell, April 2004, p. 557-560, Vol. 3, No. 2
1535-9778/04/$08.00+0     DOI: 10.1128/EC.3.2.557-560.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

A Mitogen-Activated Protein Kinase That Senses Nitrogen Regulates Conidial Germination and Growth in Aspergillus fumigatus

Tao Xue, C. Kim Nguyen, Angela Romans, and Gregory S. May*

Division of Pathology and Laboratory Medicine and Genes and Development Graduate Program, The University of Texas M. D. Anderson Cancer Center, Houston, Texas

Received 6 November 2003/ Accepted 23 January 2004

We show that the mitogen-activated protein (MAP) kinase pathway that responds to osmotic stress in Aspergillus fumigatus is also involved in nutritional sensing. This MAP kinase regulates conidial germination in response to the nitrogen source and is activated upon starvation for either carbon or nitrogen during vegetative growth.

* Corresponding author. Mailing address: Division of Pathology and Laboratory Medicine, Unit 54, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030. Phone: (713) 745-1945. Fax: (713) 792-8460. E-mail: gsmay{at}mdanderson.org.

Eukaryotic Cell, April 2004, p. 557-560, Vol. 3, No. 2
1535-9778/04/$08.00+0     DOI: 10.1128/EC.3.2.557-560.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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