This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zeiner, G. M.
Right arrow Articles by Campbell, D. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zeiner, G. M.
Right arrow Articles by Campbell, D. A.

 Previous Article

Eukaryotic Cell, February 2004, p. 241-244, Vol. 3, No. 1
1535-9778/04/$08.00+0     DOI: 10.1128/EC.3.1.241-244.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

SmD1 Is Required for Spliced Leader RNA Biogenesis

Gusti M. Zeiner,1,{dagger} Silvie Foldynová,2,{dagger} Nancy R. Sturm,1 Julius Lukes,2 and David A. Campbell1*

Department of Microbiology, Immunology & Molecular Genetics, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095-1489,1 Institute of Parasitology, Czech Academy of Sciences, and Faculty of Biology, University of South Bohemia, Ceské Budejovice, Czech Republic2

Received 22 August 2003/ Accepted 10 December 2003

The Sm-binding site of the kinetoplastid spliced leader RNA has been implicated in accurate spliced leader RNA maturation and trans-splicing competence. In Trypanosoma brucei, RNA interference-mediated knockdown of SmD1 caused defects in spliced leader RNA maturation, displaying aberrant 3'-end formation, partial formation of cap 4, and overaccumulation in the cytoplasm; U28 pseudouridylation was unaffected.

* Corresponding author. Mailing address: Department of Microbiology, Immunology & Molecular Genetics, David Geffen School of Medicine at UCLA, University of California at Los Angeles, 609 Charles E. Young Dr. East, Los Angeles, CA 90095-1489. Phone: (310) 206-5556. Fax: (310) 206-5231. E-mail: dc{at}ucla.edu.

{dagger} G.M.Z. and S.F. contributed equally to this work.

Eukaryotic Cell, February 2004, p. 241-244, Vol. 3, No. 1
1535-9778/04/$08.00+0     DOI: 10.1128/EC.3.1.241-244.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Zamudio, J. R., Mittra, B., Chattopadhyay, A., Wohlschlegel, J. A., Sturm, N. R., Campbell, D. A. (2009). Trypanosoma brucei Spliced Leader RNA Maturation by the Cap 1 2'-O-Ribose Methyltransferase and SLA1 H/ACA snoRNA Pseudouridine Synthase Complex. Mol. Cell. Biol. 29: 1202-1211 [Abstract] [Full Text]  
  • Hury, A., Goldshmidt, H., Tkacz, I. D., Michaeli, S. (2009). Trypanosome Spliced-Leader-Associated RNA (SLA1) Localization and Implications for Spliced-Leader RNA Biogenesis. Eukaryot Cell 8: 56-68 [Abstract] [Full Text]  
  • Scofield, D. G., Lynch, M. (2008). Evolutionary Diversification of the Sm Family of RNA-Associated Proteins. Mol Biol Evol 25: 2255-2267 [Abstract] [Full Text]  
  • Zamudio, J. R., Mittra, B., Foldynova-Trantirkova, S., Zeiner, G. M., Lukes, J., Bujnicki, J. M., Sturm, N. R., Campbell, D. A. (2007). The 2'-O-Ribose Methyltransferase for Cap 1 of Spliced Leader RNA and U1 Small Nuclear RNA in Trypanosoma brucei. Mol. Cell. Biol. 27: 6084-6092 [Abstract] [Full Text]  
  • Zhang, H., Hou, Y., Miranda, L., Campbell, D. A., Sturm, N. R., Gaasterland, T., Lin, S. (2007). Spliced leader RNA trans-splicing in dinoflagellates. Proc. Natl. Acad. Sci. USA 104: 4618-4623 [Abstract] [Full Text]  
  • Zamudio, J. R., Mittra, B., Zeiner, G. M., Feder, M., Bujnicki, J. M., Sturm, N. R., Campbell, D. A. (2006). Complete Cap 4 Formation Is Not Required for Viability in Trypanosoma brucei. Eukaryot Cell 5: 905-915 [Abstract] [Full Text]  
  • ARHIN, G. K., LI, H., ULLU, E., TSCHUDI, C. (2006). A protein related to the vaccinia virus cap-specific methyltransferase VP39 is involved in cap 4 modification in Trypanosoma brucei. RNA 12: 53-62 [Abstract] [Full Text]  
  • Deng, W., Zhu, X., Skogerbo, G., Zhao, Y., Fu, Z., Wang, Y., He, H., Cai, L., Sun, H., Liu, C., Li, B., Bai, B., Wang, J., Jia, D., Sun, S., He, H., Cui, Y., Wang, Y., Bu, D., Chen, R. (2006). Organization of the Caenorhabditis elegans small non-coding transcriptome: Genomic features, biogenesis, and expression. Genome Res 16: 20-29 [Abstract] [Full Text]  
  • Zeiner, G. M., Hitchcock, R. A., Sturm, N. R., Campbell, D. A. (2004). 3'-End Polishing of the Kinetoplastid Spliced Leader RNA Is Performed by SNIP, a 3'->5' Exonuclease with a Motley Assortment of Small RNA Substrates. Mol. Cell. Biol. 24: 10390-10396 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»