This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Catlett, N. L.
Right arrow Articles by Turgeon, B. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Catlett, N. L.
Right arrow Articles by Turgeon, B. G.

 Previous Article  |  Next Article 

Eukaryotic Cell, December 2003, p. 1151-1161, Vol. 2, No. 6
1535-9778/03/$08.00+0     DOI: 10.1128/EC.2.6.1151-1161.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Whole-Genome Analysis of Two-Component Signal Transduction Genes in Fungal Pathogens

Natalie L. Catlett,{dagger} Olen C. Yoder,{ddagger} and B. Gillian Turgeon*

Torrey Mesa Research Institute/Syngenta Research and Technology, San Diego, California 92121

Received 14 March 2003/ Accepted 16 July 2003

Two-component phosphorelay systems are minimally comprised of a histidine kinase (HK) component, which autophosphorylates in response to an environmental stimulus, and a response regulator (RR) component, which transmits the signal, resulting in an output such as activation of transcription, or of a mitogen-activated protein kinase cascade. The genomes of the yeasts Saccharomyces cerevisiae, Schizosaccharomyces pombe, and Candida albicans encode one, three, and three HKs, respectively. In contrast, the genome sequences of the filamentous ascomycetes Neurospora crassa, Cochliobolus heterostrophus (Bipolaris maydis), Gibberella moniliformis (Fusarium verticillioides), and Botryotinia fuckeliana (Botrytis cinerea) encode an extensive family of two-component signaling proteins. The putative HKs fall into 11 classes. Most of these classes are represented in each filamentous ascomycete species examined. A few of these classes are significantly more prevalent in the fungal pathogens than in the saprobe N. crassa, suggesting that these groups contain paralogs required for virulence. Despite the larger numbers of HKs in filamentous ascomycetes than in yeasts, all of the ascomycetes contain virtually the same downstream histidine phosphotransfer proteins and RR proteins, suggesting extensive cross talk or redundancy among HKs.

* Corresponding author. Permanent address: Department of Plant Pathology, 334 Plant Sciences Bldg., Cornell University, Ithaca, NY 14853. Phone: (607) 254-7458. Fax: (607) 255-8835. E-mail: bgt1{at}cornell.edu.

{dagger} Present address: Plant and Microbial Biology Department, University of California, Berkeley, CA 94720.

{ddagger} Present address: Diversa Corporation, San Diego, CA 92121.

Eukaryotic Cell, December 2003, p. 1151-1161, Vol. 2, No. 6
1535-9778/03/$08.00+0     DOI: 10.1128/EC.2.6.1151-1161.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Dongo, A., Bataille-Simoneau, N., Campion, C., Guillemette, T., Hamon, B., Iacomi-Vasilescu, B., Katz, L., Simoneau, P. (2009). The Group III Two-Component Histidine Kinase of Filamentous Fungi Is Involved in the Fungicidal Activity of the Bacterial Polyketide Ambruticin. Appl. Environ. Microbiol. 75: 127-134 [Abstract] [Full Text]  
  • Bahn, Y.-S. (2008). Master and Commander in Fungal Pathogens: the Two-Component System and the HOG Signaling Pathway. Eukaryot Cell 7: 2017-2036 [Full Text]  
  • Chauhan, N., Calderone, R. (2008). Two-Component Signal Transduction Proteins as Potential Drug Targets in Medically Important Fungi. Infect. Immun. 76: 4795-4803 [Full Text]  
  • Plemenitas, A., Vaupotic, T., Lenassi, M., Kogej, T., Gunde-Cimerman, N. (2008). Adaptation of extremely halotolerant black yeast Hortaea werneckii to increased osmolarity: a molecular perspective at a glance.. SIM 61: 67-75 [Abstract] [Full Text]  
  • Bahn, Y.-S., Geunes-Boyer, S., Heitman, J. (2007). Ssk2 Mitogen-Activated Protein Kinase Kinase Kinase Governs Divergent Patterns of the Stress-Activated Hog1 Signaling Pathway in Cryptococcus neoformans. Eukaryot Cell 6: 2278-2289 [Abstract] [Full Text]  
  • Hane, J. K., Lowe, R. G.T., Solomon, P. S., Tan, K.-C., Schoch, C. L., Spatafora, J. W., Crous, P. W., Kodira, C., Birren, B. W., Galagan, J. E., Torriani, S. F.F., McDonald, B. A., Oliver, R. P. (2007). Dothideomycete Plant Interactions Illuminated by Genome Sequencing and EST Analysis of the Wheat Pathogen Stagonospora nodorum. Plant Cell 19: 3347-3368 [Abstract] [Full Text]  
  • Vetcher, L., Menzella, H. G., Kudo, T., Motoyama, T., Katz, L. (2007). The Antifungal Polyketide Ambruticin Targets the HOG Pathway. Antimicrob. Agents Chemother. 51: 3734-3736 [Abstract] [Full Text]  
  • Chapeland-Leclerc, F., Paccallet, P., Ruprich-Robert, G., Reboutier, D., Chastin, C., Papon, N. (2007). Differential Involvement of Histidine Kinase Receptors in Pseudohyphal Development, Stress Adaptation, and Drug Sensitivity of the Opportunistic Yeast Candida lusitaniae. Eukaryot Cell 6: 1782-1794 [Abstract] [Full Text]  
  • Vargas-Perez, I., Sanchez, O., Kawasaki, L., Georgellis, D., Aguirre, J. (2007). Response Regulators SrrA and SskA Are Central Components of a Phosphorelay System Involved in Stress Signal Transduction and Asexual Sporulation in Aspergillus nidulans. Eukaryot Cell 6: 1570-1583 [Abstract] [Full Text]  
  • Izumitsu, K., Yoshimi, A., Tanaka, C. (2007). Two-Component Response Regulators Ssk1p and Skn7p Additively Regulate High-Osmolarity Adaptation and Fungicide Sensitivity in Cochliobolus heterostrophus. Eukaryot Cell 6: 171-181 [Abstract] [Full Text]  
  • Pareek, A., Singh, A., Kumar, M., Kushwaha, H. R., Lynn, A. M., Singla-Pareek, S. L. (2006). Whole-Genome Analysis of Oryza sativa Reveals Similar Architecture of Two-Component Signaling Machinery with Arabidopsis. Plant Physiol. 142: 380-397 [Abstract] [Full Text]  
  • Bahn, Y.-S., Kojima, K., Cox, G. M., Heitman, J. (2006). A Unique Fungal Two-Component System Regulates Stress Responses, Drug Sensitivity, Sexual Development, and Virulence of Cryptococcus neoformans. Mol. Biol. Cell 17: 3122-3135 [Abstract] [Full Text]  
  • Bourret, R. B. (2006). Census of prokaryotic senses.. J. Bacteriol. 188: 4165-4168 [Full Text]  
  • Goswami, R. S., Xu, J.-R., Trail, F., Hilburn, K., Kistler, H. C. (2006). Genomic analysis of host-pathogen interaction between Fusarium graminearum and wheat during early stages of disease development. Microbiology 152: 1877-1890 [Abstract] [Full Text]  
  • Froehlich, A. C., Noh, B., Vierstra, R. D., Loros, J., Dunlap, J. C. (2005). Genetic and Molecular Analysis of Phytochromes from the Filamentous Fungus Neurospora crassa. Eukaryot Cell 4: 2140-2152 [Abstract] [Full Text]  
  • Yoshimi, A., Kojima, K., Takano, Y., Tanaka, C. (2005). Group III Histidine Kinase Is a Positive Regulator of Hog1-Type Mitogen-Activated Protein Kinase in Filamentous Fungi. Eukaryot Cell 4: 1820-1828 [Abstract] [Full Text]  
  • Zhang, W., Shi, L. (2005). Distribution and evolution of multiple-step phosphorelay in prokaryotes: lateral domain recruitment involved in the formation of hybrid-type histidine kinases. Microbiology 151: 2159-2173 [Abstract] [Full Text]  
  • Wang, C., St. Leger, R. J. (2005). Developmental and Transcriptional Responses to Host and Nonhost Cuticles by the Specific Locust Pathogen Metarhizium anisopliae var. acridum. Eukaryot Cell 4: 937-947 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»