Eukaryotic Cell
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Eukaryotic Cell, October 2003, p. 1132-1136, Vol. 2, No. 5
1535-9778/03/$08.00+0     DOI: 10.1128/EC.2.5.1132-1136.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Biosynthesis of Glycosylphosphatidylinositol Is Essential to the Survival of the Protozoan Parasite Toxoplasma gondii

Michael J. Wichroski and Gary E. Ward*

Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, Vermont 05405

Received 7 April 2003/ Accepted 7 August 2003

The PIGA gene from Toxoplasma gondii has been cloned and characterized. Like mammalian PIGA, the transmembrane and C-terminal domains are sufficient to direct localization to the parasite endoplasmic reticulum. A functional copy of PIGA is required for tachyzoite viability, demonstrating that glycosylphosphatidylinositol biosynthesis is an essential process in T. gondii.

* Corresponding author. Mailing address: Department of Microbiology and Molecular Genetics, 316 Stafford Hall, University of Vermont, Burlington, VT 05405. Phone: (802) 656-4868. Fax: (802) 656-8749. E-mail: gward{at}zoo.uvm.edu.

Eukaryotic Cell, October 2003, p. 1132-1136, Vol. 2, No. 5
1535-9778/03/$08.00+0     DOI: 10.1128/EC.2.5.1132-1136.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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