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Eukaryotic Cell, October 2003, p. 1128-1131, Vol. 2, No. 5
1535-9778/03/$08.00+0     DOI: 10.1128/EC.2.5.1128-1131.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Neutral-Lipid Analysis Reveals Elevation of Acylglycerols and Lack of Cholesterol Esters in Plasmodium falciparum-Infected Erythrocytes

Parwez Nawabi, Athanasios Lykidis, Darder Ji,{dagger} and Kasturi Haldar*

Departments of Pathology and Microbiology-Immunology, Northwestern University Medical School, Chicago, Illinois 60611

Received 24 May 2003/ Accepted 4 August 2003

Here we show that blood-stage Plasmodium falciparum organisms accumulate a high mass of triacylglycerol and diacylglycerol. However, we failed to detect cholesterol esters, a second neutral lipid species reported to be important for a related apicomplexan, Toxoplasma gondii. Evidence for P. falciparum and T. gondii homologues of acyl coenzyme A:diacylglycerol acyltransferase suggests that acylglycerols may be the conserved neutral lipids in apicomplexans.

* Corresponding author. Mailing address: Departments of Pathology and Microbiology-Immunology, Ward Bldg., Rm. 3-240, Northwestern University, The Feinberg School of Medicine, 303 Chicago Ave., Chicago, IL 60611. Phone: (312) 503-0224. Fax: (312) 503-8240. E-mail: k-haldar{at}northwestern.edu.

{dagger} Present address: Institute of Preventive Medicine, National Defense Medical Center, Sanhsia, Taipei, Taiwan.

Eukaryotic Cell, October 2003, p. 1128-1131, Vol. 2, No. 5
1535-9778/03/$08.00+0     DOI: 10.1128/EC.2.5.1128-1131.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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