Previous Article
Eukaryotic Cell, June 2003, p. 651-653, Vol. 2, No. 3
1535-9778/03/$08.00+0 DOI: 10.1128/EC.2.3.651-653.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.
Evidence that Synthesis of the Saccharomyces cerevisiae Mitochondrially Encoded Ribosomal Protein Var1p May Be Membrane Localized
Alessandro Fiori,1 Thomas L. Mason,2 and Thomas D. Fox1*
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853,1
Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, Massachusetts 010032
Received 16 January 2003/
Accepted 14 March 2003
The 5'-untranslated leaders of mitochondrial mRNAs appear to localize translation within the organelle. VAR1 is the only yeast mitochondrial gene encoding a major soluble protein. A chimeric mRNA bearing the VAR1 untranslated regions and the coding sequence for pre-Cox2p appears to be translated at the inner membrane surface. We propose that translation of the ribosomal protein Var1p is also likely to occur in close proximity to the inner membrane.
* Corresponding author. Mailing address: Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853. Phone: (607) 254-4835. Fax: (607) 255-6249. E-mail: tdf1{at}cornell.edu.
Eukaryotic Cell, June 2003, p. 651-653, Vol. 2, No. 3
1535-9778/03/$08.00+0 DOI: 10.1128/EC.2.3.651-653.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.
This article has been cited by other articles:
-
Nouet, C., Bourens, M., Hlavacek, O., Marsy, S., Lemaire, C., Dujardin, G.
(2007). Rmd9p Controls the Processing/Stability of Mitochondrial mRNAs and Its Overexpression Compensates for a Partial Deficiency of Oxa1p in Saccharomyces cerevisiae. Genetics
175: 1105-1115
[Abstract]
[Full Text]
-
Williams, E. H., Butler, C. A., Bonnefoy, N., Fox, T. D.
(2007). Translation Initiation in Saccharomyces cerevisiae Mitochondria: Functional Interactions Among Mitochondrial Ribosomal Protein Rsm28p, Initiation Factor 2, Methionyl-tRNA-Formyltransferase and Novel Protein Rmd9p. Genetics
175: 1117-1126
[Abstract]
[Full Text]
-
Williams, E. H., Bsat, N., Bonnefoy, N., Butler, C. A., Fox, T. D.
(2005). Alteration of a Novel Dispensable Mitochondrial Ribosomal Small-Subunit Protein, Rsm28p, Allows Translation of Defective COX2 mRNAs. Eukaryot Cell
4: 337-345
[Abstract]
[Full Text]
Copyright © 2003 by the American Society for Microbiology.