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Eukaryotic Cell, April 2002, p. 311-314, Vol. 1, No. 2
1535-9778/02/$04.00+0     DOI: 10.1128/EC.1.2.311-314.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Molecular Characterization of a Cystathionine Beta-Synthase Gene, CBS1, in Magnaporthe grisea

Sze Chung Clive Lo,* Lisbeth Hamer, and John E. Hamer

Microbial Research, Paradigm Genetics, Inc., Research Triangle Park, North Carolina 27709

Received 26 October 2001/ Accepted 15 January 2002

CBS1 from Magnaporthe grisea is a structural and functional homolog of the cystathionine ß-synthase (CBS) gene from Saccharomyces cerevisiae. Our studies indicated that M. grisea can utilize homocysteine and methionine through a CBS-independent pathway. The results also revealed responses of M. grisea to homocysteine that are reminiscent of human homocystinuria.

* Corresponding author. Mailing address: Paradigm Genetics, Inc., 108 Alexander Dr., Research Triangle Park, NC 27709. Phone: (919) 425-3000. Fax: (919) 544-8094. E-mail: clo{at}paragen.com.

Eukaryotic Cell, April 2002, p. 311-314, Vol. 1, No. 2
1535-9778/02/$04.00+0     DOI: 10.1128/EC.1.2.311-314.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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